79-FOLD ACCELERATED TOMOGRAPHY

Double-tilt, 166-View Reconstruction, Center Slice: Spiroplasma Melliferum

FPB using manually labeled gold bead markers for alignment of projections.
Data kindly provided by NIBIB, NIH

High-Efficiency CT: Method of Reconstruction with Progressive Resolution

Canine

Canine myocardial contrast dye perfusion.

Canine myocardial contrast dye perfusion, pre-systole with coronary vessels.

Canine myocardial contrast dye perfusion at systole with coronary vessels.

Canine myocardial contrast dye perfusion, pre-systole.
Coronary vessels removed, reconstructed with High-Efficiency CT from 3 bi-plane projections

Canine myocardial contrast dye perfusion at systole;
Coronary vessels removed, reconstructed with High-Efficiency CT from 3 bi-plane projections

Myocardial Perfusion

Plastic Model

Physical plastic model with hydraulic pump to simulate coronary arteries of a beating heart, data acquisition and control system in the background, power supply for the hydraulic beat-pump to the right. Observe the red plastic stenoses inserted in the plastic tubes and the diameter changes of connected plastic tubes.
The model operates in the water-filled plastic container.

X-ray image of Hydraulic Model during contrast dye injection showing stenosis and changes in tube diameter. Raw digital image, recorded at 30 frames / second.

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Front view of hydraulic model during contrast dye injection, logarithmic density correction (upright).

Side view of hydraulic model during contrast dye injection, logarithmic density correction (upright).

Perspective view of the reconstructed beating coronary artery model.

Perspective side-view of the reconstructed beating coronary artery model.

Numerical: Coronary Simulation

Numerical object simulation with three branches representing a coronary tree and three stenoses at branch-points.

Reconstruction of simulated branches and stenoses from 6 cone-beam projections.

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Numerical: Semisphere Simulation

HIGH efficiency CT, startup iterations. Automated alignment w/o use of manually labeled beats.

Numerical semisphere, bottom view.

Reconstruction from 4 cone-beam projections, top-view, 1 iteration.

Reconstruction from 4 cone-beam projections, bottom-view, 1 iteration.

Reconstruction from 18 cone-beam projections, top-view, 1 iteration.

Reconstruction from 18 cone-beam projections, bottom-view, 1 iteration.

Numerical: Noise test / NIBIB

Three input projections of sparse 49 noisy cube projections, range from -72 to +72 degrees.
Provided by NIBIB of NIH

Magnified 0-degree projection of input data.

Magnified, central slice of HECT reconstruction from 49 projections.

Magnified, residuals at 0 degree projection of traditional maximum entropy (MENT) reconstruction after 15 iterations.
Provided by NIBIB of NIH for error comparison.

Magnified, corresponding residuals at 0 degree projection with High Efficiency Computed Tomography (HECT) after 1 full resolution reconstruction.

Team

Wolfram R. Jarisch, Ph.D.

Founder, President
LinkedIn

Licia A. Salice-Jarisch, CFA

CEO
LinkedIn

Patent Information

Country

China

France

Germany

Japan

Taiwan

United Kingdom

USA

Patent Information

High Efficiency CT
US: 8,660,328, 8,660,330, 10,607,378, 10,789,743
IN: 334,717;
PCT: EP2310840
CN: 200980123522.8, ZL 201180035037.2
JP: JP5543448B2;
TW I555514;
Intl. pending: see WIPO/PCT;
JP2019535405A

Mammography: US: 11,123,032;

Relevant Sources – EP Smart Search, WIPO , USPTO, JPO